After bio-microneedling (sponge spicule )treatment, the blood circulation is accelerated and the metabolic rate is increased, which will shorten the keratinization period of 28 days (4 to 6 weeks for normal people) to 72 to 120 hours. After activating the cells, the skin regards the implantation at the dermis, as a kind of stress, and reduces the immune function, and after the herpes virus latent in the nerve endings is activated by the operation, it spreads to the skin along with the nerves, especially around the mouth and around the mouth. Blisters occur around the jaw, and blisters that often occur due to heat, sunlight, emotional stress, excessive fatigue, menstruation, etc., may also appear after treatment.